University of Calgary researcher Dr. Jeff Dunn is interviewed about new technology developed by the university to detect and monitor concussions. (Jeff McIntosh/The Canadian Press)

Calgary scientists use MRIs to curb use of rats, mice in medical research

Researchers use a small MRI to test possible treatments for cancer, strokes and multiple sclerosis

Medical scientists at the University of Calgary have taken steps to minimize the impact on mice and rats used in their experiments.

The university’s Cumming School of Medicine is outfitted with a small MRI that researchers use as they test possible treatments for cancer, strokes and multiple sclerosis.

“It’s one of the premier ones in Canada,” said Jeff Dunn, director of the school’s Experimental Imaging Centre.

“Anything under 500 grams fits in there, so mostly rats and mice. We use those in medical research obviously for preclinical assessment, how the disease progresses and possibly even more importantly if the treatment is functional.”

The MRI has been in use since 2004. The lab is also equipped with a blood gas analyzer, so tests can be done using blood samples taken from the animals in much the same way they are collected from human patients.

It’s a far cry from when scientists would use rats and mice and have to dissect them at every test stage.

“It really reduces the use of animals in research because, for a time-course study of treatment, we don’t have to do a whole bunch of animals,” Dunn said.

“You can take a small number and follow them over months to see how the treatment is working.”

Any research facility receiving government funding is subject to rules set out by the Canadian Council on Animal Care.

Spokeswoman Sandra MacInnis says the organization wants to ensure animal-based science in Canada takes place only when necessary and that the animals receive optimal care.

“For example, when selecting a research model, they must first consider all possible alternatives to animal models, such as computer or cell-culture models,” she wrote in an email.

The executive director of the Vancouver-based Animals in Science Policy Institute says efforts by the University of Calgary and others to use the equipment are a matter of debate.

Elisabeth Ormandy, a former researcher, said putting a mouse under an MRI scanner requires sedation or anesthesia and could be considered a source of distress for an animal since it could happen several times.

“It depends on our own personal ethics,” Ormandy said. “For people who care about that one individual mouse, that (MRI) might still not be OK.”

But she said some people might argue “it’s better to cause a little bit more suffering to one mouse instead of moderate suffering to 10 mice.”

An animal rights organization said there’s no need to use animals in tests at all when computer modelling can be just as useful.

“All things else being equal, certainly hurting and killing fewer animals is better than hurting and killing more animals,” said Jeremy Beckham, research associate with People for the Ethical Treatment of Animals.

But he said that loses the bigger question a little bit.

“There’s not any real basis to think they feel pain any less than, say, a dog or a cat,” Beckham said.

“We’ve bred dogs and cats to be our companions, so we’ve got a little bit more of an emotional attachment to them. But the ethical issues of using rats and mice are staring us in the face just as strongly.”

Bill Graveland, The Canadian Press

Just Posted

Supporters rally for Jason Kenney as UCP leader stops in Red Deer

Kenney promises equalization reform, stopping ‘Trudeau-Notley’ payroll hike, trade, economic mobility

Motown Soul celebrates ‘greats’ of classic era

Show pays tribute to Diana Ross and The Supremes, The Temptations, Marvin Gaye among others

Women of Excellence Awards introduces ‘Women of Excellence in Construction’

Gala will take place June 19th at the Sheraton Red Deer

Check online to make sure you’re registered to vote in upcoming provincial election

Advance polls open Tuesday, April 9th to Saturday, April 13th

VIDEO: Restaurant robots are already in Canada

Robo Sushi in Toronto has waist-high robots that guide patrons to empty seats

1,300 cruise ship passengers rescued by helicopter amid storm off Norway’s coast

Rescue teams with helicopters and boats were sent to evacuate the cruise ship under extremely difficult circumstances

B.C. university to offer first graduate program on mindfulness in Canada

University of the Fraser Valley says the mostly-online program focuses on self-care and well being

Sentencing judge in Broncos crash calls for carnage on highways to end

Judge Inez Cardinal sentenced Jaskirat Singh Sidhu to eight years

‘Families torn apart:’ Truck driver in fatal Broncos crash gets 8-year sentence

Judge Inez Cardinal told court in Melfort, Sask., that Sidhu’s remorse and guilty plea were mitigating factors

WestJet sticking with Boeing 737 Max once planes certified to fly

WestJet had expected to add two more of the planes this year to increase its fleet to 13

Fierce house cat spotted as ‘aggressor’ in face off with coyote in B.C. backyard

North Vancouver resident Norm Lee captures orange cat versus coyote in backyard showdown

Wilson-Raybould to reveal more details, documents on SNC-Lavalin affair

Former attorney general has written to the House of Commons justice committee

Most Read